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KMID : 1039220190290030289
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Journal of Korean Society of Occupational and Environmental Hygiene
2019 Volume.29 No. 3 p.289 ~ p.297
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Risk Factors for Associated with Latent Tuberculosis Infection among Former Mine Workers
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Hwang Joo-Hwan
Shin Jae-Hoon
Baek Jin-Ee
Choi Byung-Soon
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Abstract
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Objectives: To identify the positive rate of and the risk factors associated with latent tuberculosis infection(LTBI) in mine workers, the objectives of the present study evaluated those among former mine workers.
Methods: Between January 2015 and May 2017, former male mine workers who had been subjects for epidemiology research for work-related chronic obstructive pulmonary disease(COPD) and had received QuantiFERON-TB® Gold In-Tube(QFT-GIT) from the Institute of Occupation and Environment(IOE) under Korea Workers’ Compensation and Welfare Service(KCOMWEL) were selected as the study subjects. To identify significant variables for increased risk of LTBI, logistic regression analysis was performed.
Results: A total of 736 male former mine workers were selected as study subjects. The positive rate of LTBI among subjects was 69.2%(509/736). The current smoking[odds ratio(OR), 2.3; 95% confidence interval(CI), 1.1-4.9], COPD(OR, 1.4; 95% CI, 0.9-2.3), department loading(OR, 1.8; 95% CI, 0.9-3.4) and mining(OR, 1.5; 95% CI, 0.9-2.5), and working duration of over 20(OR, 1.6; 95% CI, 0.9-3.1) and over 30 years(OR, 2.2; 95% CI, 0.9-4.9) were associated with increased risk of LTBI. The interferon-gamma(IFN-γ) level after stimulation with M y c o b a c t e ri u m t u b e r c u l o s i s (MTB)-specific antigens showed a significantly negative correlation with age( r =-0.126).
Conclusions: The present study determined that the high positive rate of LTBI among mine workers was associated with not only the host factors but also the occupational exposure to mine dust.
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KEYWORD
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Chronic obstructive pulmonary disease, latent tuberculosis infection, mine worker, QuantiFERON-TB® Gold In-Tube
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